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Here's the complete ingredient list for some vaxes. If I put more together, I'll add it at the end.<br><br>
All the terminology (e.g., "trace", "residual") is from the label information on file with the FDA, which is linked by the vax trade name. All quantities are per dose. The information has been rewritten and edited to avoid copyright concerns. All the information about vaxes that contain bovine material includes a statement such as the following, which I removed for brevity: "The bovine materials are from countries that the USDA has determined neither have nor are at risk of bovine spongiform encephalopathy." Multiple purification steps have also been omitted, but these can be found on the linked pages.<br><br>
A note on units:<br>
One microgram = one-millionth of a gram<br>
One nanogram = one-billionth of a gram<br>
One gram = 0.035 ounces<br>
Lf = limit flocculation, a unit of measure for toxins (I don't have conversion information; I believe this is measurement unique to each substance and established initially by assay)<br><br>
...<br><br><a href="http://www.fda.gov/cber/label/dtapsan110806LB.pdf" target="_blank">Daptacel</a> (diphtheria, tetanus, acellular pertussis)<br><br>
10 micrograms detoxified pertussis toxin<br>
5 micrograms filamentous haemagglutinin<br>
5 micrograms fimbriae types 2 and 3 (FIM)<br>
3 micrograms pertactin (PRN)<br>
15 Lf (limit flocculation) diphtheria toxoid<br>
5 Lf (limit flocculation) tetanus toxoid<br>
1.5 mg aluminum phosphate (0.33 mg of aluminum)<br>
5 micrograms or less of residual formaldehyde<br>
50 nanograms or less of residual glutaraldehyde<br>
3.3 mg (0.6% v/v) 2-phenoxyethanol<br><br>
- Pertussis:<br>
Bordetella pertussis cultures grown in Stainer-Scholte medium, with added casamino acids and dimethyl-beta-cyclodextrin.<br>
Toxin detoxified with glutaraldehyde.<br>
Filamentous hemagglutinin is treated with formaldehyde.<br>
Residual aldehydes are removed by ultrafiltration.<br>
Individual antigens adsorbed separately onto aluminum phosphate.<br><br>
- Diphtheria:<br>
Corynebacterium diphtheriae cultures grown in modified Mueller’s growth medium.<br>
Toxin purified by ammonium sulfate fractionation and detoxified with formaldehyde and diafiltered.<br>
Toxoid is individually adsorbed onto aluminum phosphate<br><br>
- Tetanus:<br>
Clostridium tetan: cultures grown in modified Mueller-****** casamino acid medium without beef heart infusion.<br>
Toxin is detoxified with formaldehyde and purified by ammonium sulfate fractionation and diafiltration.<br>
Toxoid individually adsorbed onto aluminum phosphate.<br><br>
…<br><br><a href="http://www.fda.gov/cber/label/dtapsmi121302LB.pdf" target="_blank">Pediarix</a> (diphtheria, tetanus, acellular pertussis)<br><br>
25 Lf diphtheria toxoid<br>
10 Lf of tetanus toxoid<br>
25 micrograms inactivated pertussis toxin<br>
25 micrograms filamentous hemagglutinin<br>
8 micrograms pertactin<br>
10 micrograms HBsAg (hepatitis B surface antigen)<br>
40 D-antigen Units (DU) of Type 1 poliovirus<br>
8 DU of Type 2 poliovirus<br>
32 DU of Type 3 poliovirus<br>
2.5 mg 2-phenoxyethanol (a preservative)<br>
4.5 mg sodium chloride<br>
Not more than 0.85 mg aluminum by assay<br>
100 micrograms or less residual formaldehyde<br>
100 micrograms or less polysorbate 80 (Tween 80)<br>
Thimerosal is used at the early stages of manufacture and is removed by subsequent purification steps to below the analytical limit of detection (less than 25 nanograms mercury per 20 micrograms HBsAg) which upon calculation is less than 12.5 nanograms mercury per dose<br>
0.05 nanograms or less of Neomycin<br>
0.01 nanograms or less of polymyxin B<br>
5% or less of yeast protein<br><br>
- Diphtheria:<br>
Corynebacterium diphtheriae cultures grown in Fenton medium containing a bovine extract.<br><br>
- Tetanus:<br>
Clostridium tetani cultures grown in a modified Latham medium derived from bovine casein.<br>
Detoxified with formaldehyde.<br>
Purified by precipitation, dialysis, and sterile filtration<br><br>
- Pertussis:<br>
Bordetella pertussis cultures grown in modified Stainer-Scholte liquid medium.<br>
Toxin detoxified with glutaraldehyde and formaldehyde.<br>
Filamentous hemagglutinin and pertactin, two pertussis antigens, are treated with formaldehyde.<br><br>
- Hepatitis B surface antigen (HBsAg):<br>
Genetically engineered Saccharomyces cerevisiae cells, which carry the surface antigen gene of the hepatitis B virus, are cultured in a synthetic medium.<br>
The surface antigen is purified by precipitation, ion exchange chromatography, and ultrafiltration.<br>
Residual thimerosal removed by dialysis with cysteine.<br><br>
- Polio:<br>
Each strain is individually grown in VERO cells, a continuous line of monkey kidney cells, cultivated on microcarriers. Calf serum and lactalbumin hydrolysate are used during culture.<br>
Each viral suspension is inactivated with formaldehyde.<br><br>
…<br><br><a href="http://www.fda.gov/cber/label/pneuwye112206lb.pdf" target="_blank">Prevnar</a> (pneumococcal 7-valent conjugate, contains the capsular antigens of Streptococcus pneumoniae serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F individually conjugated to diphtheria CRM 197 protein)<br><br>
2 micrograms of each saccharide for serotypes 4, 9V, 14, 18C, 19F, and 23F<br>
4 micrograms serotype 6B per dose<br>
Approximately 20 micrograms CRM197 carrier protein<br>
0.125 mg aluminum per 0.5 mL dose as aluminum phosphate adjuvant<br><br>
- Diphtheria:<br>
Corynebacterium diphtheriae strain C7 (197) cultures grown in a casamino acids and yeast extract-based medium.<br>
CRM197, a nontoxic variant of diphtheria toxin, is purified through ultrafiltration, ammonium 25 sulfate precipitation, and ion-exchange chromatography.<br><br>
- Each Streptococcus pneumoniae serotype is grown in soy peptone broth.<br><br>
…<br><br><a href="http://www.fda.gov/cber/label/dtapcon073196Lb.pdf" target="_blank"><br>
Tripedia</a> (diphtheria, acellular pertussis, tetanus)<br><br>
6.7 Lf of diphtheria toxoid<br>
5 Lf of tetanus toxoid<br>
46.8 micrograms of pertussis antigens. This is represented in the final vaccine as approximately 23.4 micrograms of inactivated pertussis toxin and 23.4 micrograms of filamentous hemagglutinin.<br>
Not more than 0.170 mg of aluminum<br>
Not more than 100 micrograms (0.02%) of residual formaldehyde<br>
Unspecified amounts of gelatin<br>
Unspecified amounts of polysorbate 80<br><br>
- Diphtheria:<br>
Corynebacterium diphtheriae cultures are grown in a modified Mueller and ****** medium.<br>
Toxin detoxified with formaldehyde.<br>
Purified by ammonium sulfate fractionation and diafiltration.<br>
Toxiods are adsorbed using aluminum potassium sulfate.<br><br>
- Tetanus:<br>
Clostridium tetani cultures are grown in a peptone-based medium containing a bovine extract.<br>
Toxin detoxified with formaldehyde.<br>
Purified by ammonium sulfate fractionation and diafiltration.<br>
Toxiods are adsorbed using aluminum potassium sulfate.<br><br>
- Pertussis:<br>
Phase 1 Bordetella pertussis cultures grown in a modified Stainer-Scholte medium.<br><br>
…<br><br><a href="http://www.fda.gov/cber/label/dtapgla070703LB.pdf" target="_blank">Infanrix</a> (diphtheria, tetanus, acellular pertussis)<br><br>
25 Lf diphtheria toxoid<br>
10 Lf of tetanus toxoid<br>
25 micrograms inactivated pertussis toxin<br>
25 micrograms filamentous hemagglutinin<br>
8 microgram pertactin.<br>
2.5 mg phenoxyethanol<br>
4.5 micrograms sodium chloride<br>
Not more than 0.625 mg aluminum by assay<br>
100 micrograms or less of residual formaldehyde<br>
100 micrograms or less of polysorbate 80<br><br>
- Diphtheria:<br>
Corynebacterium diphtheriae cultures grown in Fenton medium containing a bovine extract.<br>
Toxin detoxified with formaldehyde and purified by precipitation, dialysis, and sterile filtration.<br><br>
- Tetanus:<br>
Clostridium tetani cultures grown in a modified Latham medium derived from bovine casein.<br>
Toxin detoxified with formaldehyde and purified by precipitation, dialysis, and sterile filtration.<br><br>
- Pertussis:<br>
Bordetella pertussis culture grown in modified Stainer-Scholte liquid medium.<br>
Antigens are purified in successive chromatographic and precipitation steps.<br>
Toxin is detoxified using glutaraldehyde and formaldehyde.<br>
Filamentous hemagglutinin and pertactin, two pertussis antigens, are treated with formaldehyde.<br>
Each antigen is individually adsorbed onto aluminum hydroxide.<br><br>
…<br><br><a href="http://www.fda.gov/cber/label/mmrmer122906LB.pdf" target="_blank">M-M-R II</a> (measles, mumps, rubella)<br><br>
Not less than 1,000 TCID (tissue culture infectious doses) measles virus<br>
Not less than 20,000 TCID mumps virus<br>
Not less than 1,000 TCID rubella virus<br>
14.5 mg sorbitol<br>
Unspecified amount of sodium phosphate<br>
1.9 mg sucrose<br>
Unspecified amount of sodium chloride<br>
14.5 mg hydrolyzed gelatin<br>
0.3 mg or less of recombinant human albumin<br>
Less than 1 part per million of fetal bovine serum<br>
Approximately 25 micrograms of neomycin<br>
“other buffer and media ingredients”<br>
(no preservatives)<br><br>
- Measles:<br>
The measles virus is derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. Cell cultures are grown in Medium 199 (a buffered salt solution containing vitamins and amino acids and supplemented with fetal bovine serum) containing SPGA (sucrose, phosphate, glutamate, and recombinant human albumin) as stabilizer and neomycin.<br><br>
- Mumps:<br>
The mumps virus is a Jeryl Lynn (B level) strain of mumps virus propagated in chick embryo cell culture. Cell cultures are grown in Medium 199 (a buffered salt solution containing vitamins and amino acids and supplemented with fetal bovine serum) containing SPGA (sucrose, phosphate, glutamate, and recombinant human albumin) as stabilizer and neomycin.<br><br>
- Rubella:<br>
The rubella virus is a Wistar RA 27/3 strain of live attenuated rubella virus propagated in WI-38 human diploid lung fibroblasts. Cell cultures are grown in Minimum Essential Medium (a buffered salt solution containing vitamins and amino acids and supplemented with fetal bovine serum) containing recombinant human albumin and neomycin.<br>
…<br><br><a href="http://www.fda.gov/cber/label/inflave071405LB.pdf" target="_blank"><br>
Fluzone</a> (influenza)<br><br>
45 micrograms hemagglutinin, in the recommended ratio of 15 g HA each, representative of the following three prototype strains: A/New Caledonia/20/99/IVR-116 (H1N1), A/New York/55/2004/X-157 (H3N2) (an A/California/7/2004-like strain) and B/Jiangsu/10/2003 (a B/Shanghai/361/2002-like strain)<br>
0.05% gelatin (stabilizer)<br>
25 micrograms of mercury per dose from a 5 ml vial (the 0.25 ml prefilled syringe dose for 6-25 months of age, the 0.5 ml prefilled dose for 26 months and older, and the 0.5 ml vial for 36 months of age and older do not contain a preservative and thimerosal is not used in the manufacturing process of these preparations)<br><br>
- Influenza:<br>
Propagated in embryonated chicken eggs.<br>
The virus-containing fluids are inactivated with formaldehyde.<br>
The virus is chemically disrupted using a nonionic surfactant, octoxinol-9, producing a “split virus.”<br><br>
…<br><br><a href="http://www.fda.gov/cber/label/hpvmer040307LB.pdf" target="_blank">Gardasil</a> (quadrivalent Human Papillomavirus [types 6, 11, 16, 18] recombinant vaccine)<br><br>
20 micrograms HPV 6 L1 protein<br>
40 micrograms HPV 11 L1 protein<br>
40 micrograms HPV 16 L1 protein<br>
20 microgram sHPV 18 L1 protein.<br>
225 micrograms aluminum (as amorphous aluminum hydroxyphosphate sulfate adjuvant)<br>
9.56 mg of sodium chloride<br>
0.78 mg of L-histidine<br>
50 micrograms polysorbate 80<br>
35 micrograms sodium borate<br>
Water for injection (volume not specified)<br>
(no preservatives or antibiotics)<br><br>
Recombinant <i>Saccharomyces cerevisiae</i> is used to produce the major HSV capsid proteins, which self-assemble into virus-like particles (VLPs). <i>S. cerevisiae</i> is grown on chemically-defined fermentation media which include vitamins, amino acids, mineral salts, and carbohydrates.<br>
Purified VLPs are adsorbed on preformed aluminum-containing adjuvant (amorphous aluminum hydroxyphosphate sulfate).<br><br>
…<br><br><a href="http://www.fda.gov/cber/label/hbcwye111706LB.pdf" target="_blank">HibTITER</a><br><br>
Label appears to be incomplete<br>
10 micrograms purified Haemophilus b saccharide<br>
Approximately 25 micrograms CRM 197 protein<br>
(single dose 0.5 ml vial contains no preservatives)<br><br>
- Influenza:<br>
Contains the oligosaccharides of the capsular antigen of Haemophilus influenza type b, derived from capsular polysaccharide polyribosylribitol phosphatel Haemophilus b strain Eagan grown in a medium that is a mixture of mineral salts, amino acids, and cofactors.<br><br>
- Diphtheria:<br>
Contains the diphtheria CRM 197 protein (CRMI97), a nontoxic variant of the diphtheria toxin. Corynebacterium diphtheriae<br>
C7 (beta 197) cultures are grown in a casamino acids and yeast extract-based medium.<br><br>
The influenza oligosaccharides and diphtheria protein are coupled together by reductive amination. The conjugate is purified to remove unreacted protein, oligosaccharides, and reagents; and sterilized by filtration.<br><br>
…<br><a href="http://www.fda.gov/cber/label/hahbgsk032807LB.pdf" target="_blank"><br>
Twinrix</a> (Hep A and B)<br><br>
720 ELISA Units inactivated hepatitis A virus<br>
20 micrograms recombinant HBsAg protein<br>
0.45 mg aluminum (aluminum phosphate and aluminum hydroxide as adjuvants)<br>
Amino acids (quantity not specified)<br>
5.0 mg 2-phenoxyethanol (preservative)<br>
Sodium chloride (quantity not specified)<br>
Phosphate buffer (quantity not specified)<br>
polysorbate 20 (quantity not specified)<br>
Water for injection<br>
Less than 1 microgram mercry from trace amount of thimerosal Not more than 2.5 microgram MRC-5 cellular proteins<br>
Not more than 20 nanograms neomycin (from cell growth media)<br>
No more than 5% yeast protein<br><br>
- Hepatitis A:<br>
Inactivated hepatitis A virus (strain HM175) propagated in MRC-5 cells, and combined with purified surface antigen of the hepatitis B virus.<br><br>
- Hepatitis B:<br>
The hepatitis B surface antigen (HBsAg) is obtained by culturing genetically engineered Saccharomyces cerevisiae cells, which carry the surface antigen gene of the hepatitis B virus. Cultures are grown in a synthetic media containing inorganic salts, amino acids, dextrose, and vitamins.<br><br>
Each antigen is adsorbed separately onto aluminum salts.<br><br>
…<br><a href="http://www.fda.gov/cber/label/mmrvmer022707LB.pdf" target="_blank"><br>
ProQuad</a> (measles, mumps, rubella, varicella)<br><br>
3.00 log 10 TCID50 (50% tissue culture infectious dose) measles virus<br>
4.30 log10 TCID50 mumps virus<br>
3.00 log10 TCID50 rubella virus<br>
A minimum of 3.99 log10 PFU (plaque-forming units) Oka/Merck varicella virus<br>
No more than 21 mg sucrose<br>
11 mg hydrolyzed gelatin<br>
2.4 mg sodium chloride<br>
1.8 mg sorbitol<br>
0.40 mg monosodium L-glutamate<br>
0.34 micrograms sodium phosphate dibasic<br>
0.31 mg human albumin<br>
0.17 mg sodium bicarbonate<br>
72 micrograms potassium phosphate monobasic<br>
60 micrograms potassium chloride<br>
36 micrograms potassium phosphate dibasic<br>
Residual components of MRC-5 cells including DNA and protein<br>
Less than 16 micrograms neomycin<br>
0.5 microgram bovine calf serum<br>
“other buffer and media ingredients”<br>
(no preservatives)<br><br>
Contains the components of M-M-R II (Measles, Mumps and Rubella Virus Vaccine Live) and varicella virus vaccine live.<br>
M-M-R II contains 1) an attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture; 2) the Jeryl Lynn (B level) strain of mumps virus propagated in chick embryo cell culture; and 3) the Wistar RA 27/3 strain of live attenuated rubella virus propagated in WI-38 human diploid lung fibroblasts.<br>
The varicella virus is an Oka/Merck strain of varicella-zoster virus propagated in MRC-5 cells.<br><br>
…<br><br><a href="http://www.fda.gov/cber/label/mvvmer013107LB.pdf" target="_blank">Attenuvax</a> (measles)<br><br>
Not less than 1,000 TCID50 (tissue culture infectious doses) measles virus<br>
14.5 mg sorbitol<br>
Sodium phosphate (quantity not specified)<br>
1.9 mg sucrose<br>
Sodium chloride (quantity not specified)<br>
14.5 mg hydrolyzed gelatin<br>
0.3 mg human albumin<br>
Less than 1 part per million fetal bovine serum<br>
Approximately 25 micrograms neomycin<br>
“other buffer and media ingredients”<br>
(no preservatives)<br><br>
Contains an attenuated line of measles virus derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture.<br>
Cell cultures grown in Medium 199 (a buffered salt solution containing vitamins and amino acids and supplemented with fetal bovine serum) containing SPGA (sucrose, phosphate, glutamate, and human albumin) as stabilizer and neomycin.<br>
Human albumin is processed by the Cohn cold ethanol fractionation procedure.<br><br>
…<br><a href="http://www.fda.gov/cber/label/mpdtsan033007LB.pdf" target="_blank"><br>
Menactra</a> (N. meningitidis serogroups A, 4C, Y and W-135)<br><br>
Label appears to be incomplete<br>
“sodium phosphate buffered isotonic sodium chloride solution”<br>
4 micrograms each of meningococcal A,C, Y, and W-135 polysaccharide conjugated to approximately 48 micrograms diphtheria toxoid protein carrier<br>
(no preservative or adjuvant added during manufacture)<br><br>
Contains Neisseria meningitidis serogroup A, C, Y and W-135 capsular polysaccharide antigens individually conjugated to diphtheria toxoid protein.<br><br>
- Meningitis:<br>
N meningitidis strains are cultured on Mueller Hinton agar and grown in Watson Scherp media<br><br>
- Diphtheria:<br>
Corynebacterium diphtheriae cultures are grown in a modified Mueller and ****** medium and detoxified with formaldehyde.<br><br>
…<br><br><a href="http://www.fda.gov/cber/label/rotamer021207LB1.pdf" target="_blank">Rotateq</a> (rotavirus)<br><br>
Sucrose (quantity not specified)<br>
Sodium citrate (quantity not specified)<br>
Sodium phosphate monobasic monohydrate (quantity not specified)<br>
Sodium hydroxide (quantity not specified)<br>
Polysorbate 80 (quantity not specified)<br>
Cell culture media (quantity not specified)<br>
Trace amounts of fetal bovine serum<br>
(no preservatives)<br><br>
Contains 5 live reassortant rotaviruses.<br>
Parent strains of the reassortants were isolated from human and bovine hosts. Four reassortant<br>
Reassortments propagated in Vero cells.<br><br>
…<br><br><a href="http://www.fda.gov/cber/label/rvvmer013107LB.pdf" target="_blank">Meruvax II</a> (rubella)<br><br>
Not less than 1,000 TCID50 (tissue culture infectious doses) rubella virus<br>
14.5 mg sorbitol<br>
Sodium phosphate (quantity not specified)<br>
1.9 mg sucrose<br>
Sodium chloride (quantity not specified)<br>
14.5 mg hydrolyzed gelatin<br>
0.3 mg human albumin<br>
Less than 1 part per million fetal bovine serum<br>
Approximately 25 micrograms neomycin<br>
“other buffer and media ingredients”<br>
(no preservatives)<br><br>
Contains the Wistar Institute RA 27/3 strain of live attenuated rubella virus.<br>
The virus was propagated in WI-38 human diploid lung fibroblasts.<br>
Cell cultures were grown in Minimum Essential Medium (a buffered salt solution containing vitamins and amino acids and supplemented with fetal bovine serum) containing human serum albumin and neomycin.<br><br>
…<br><br><a href="http://www.fda.gov/cber/label/tubesan010807LB.pdf" target="_blank">Tubersol</a> (tuberculin purified protein derivative – diagnostic antigen)<br><br>
5 TU per 0.1 mL purified protein derivative of M tuberculosis<br>
Sterile isotonic phosphate buffered saline<br>
0.0006% Polysorbate 80<br>
0.22% to 0.35% weight-to-volume phenol<br><br>
Prepared from a large Master Batch Connaught Tuberculin (CT68).<br>
A cell-free purified protein fraction is obtained from a human strain of Mycobacterium tuberculosis that was grown on a protein-free synthetic medium and inactivated.<br><br>
…<br><br><a href="http://www.fda.gov/cber/label/varmer110906lb2.pdf" target="_blank">Varivax</a>, refrigerator-stable formulation (varicella)<br><br>
A minimum of 1350 plaque forming units (PFU) Oka/Merck varicella virus<br>
18 mg sucrose<br>
8.9 mg hydrolyzed gelatin<br>
3.6 mg urea<br>
2.3 mg sodium chloride<br>
0.36 mg monosodium L-glutamate<br>
0.33 mg sodium phosphate dibasic<br>
57 micrograms potassium phosphate monobasic<br>
57 micrograms potassium chloride<br>
Residual components of MRC-5 cells including DNA and protein<br>
Trace quantities neomycin<br>
Trace quantities bovine calf serum<br>
(no preservatives)<br><br>
A preparation of the Oka/Merck strain of live, attenuated varicella virus. The virus was obtained from a child with wild-type varicella, then introduced into human embryonic lung cell cultures, adapted to and propagated in embryonic guinea pig cell cultures and propagated in human diploid cell cultures. Further passage of the virus was performed in human diploid cell cultures.<br><br>
...<br><br><a href="http://64.233.167.104/search?q=cache:cIk5Xo8ycXAJ:www.fda.gov/cber/label/inflchi091405LB2.pdf+fluvirin+label&hl=en&ct=clnk&cd=1&gl=us&client=firefox-a" target="_blank">Fluvirin</a> (influenza types A and B)<br>
[information is for 2005-2006 formula]<br><br>
Viral antigens<br>
Trace thimerosal<br>
0.98 mcg mercury<br>
Polymyxin, neomycin, and betapropiolactone (used in manufacture) cannot be detected in the final product by current assay procedures.<br><br>
Vaccine is prepared from the extraembryonic fluid of embryonated chicken eggs inoculated with an influenza virus suspension containing neomycin and polymyxin. Three virus strains are used: 1) A/California/7/2004 (H3N2)-like); 2) A/New Caledonia/20/99 IVR-116; and B/Jiangsu/10/2003 B/Shanghai/361/2002-like. The fluid is inactivated with betapropiolactone. Hemagglutinin and neuraminidase, two surface antigens, are obtained from the influenza virus particle in a process that involves nonylphenol ethoxylate and removes most of the internal proteins. The nonylphenol ethoxylate is later removed.<br><br>
…<br><br><a href="http://64.233.167.104/search?q=cache:7HiZe3z0BWgJ:www.fda.gov/cber/label/inflgla083105LB.pdf+fluarix+label&hl=en&ct=clnk&cd=1&gl=us&client=firefox-a" target="_blank">Fluarix</a> (influenza type A and B)<br><br>
45 micrograms hemagglutinin<br>
0.085 mg or less octoxynol-10<br>
0.1 mg or less alpha- tocopheryl hydrogen succinate<br>
0.415 mg or less polysorbate 80 (Tween 80)<br>
Less than 1.24 micrograms mercury from thimerosal<br>
Less than 0.0016 micrograms hydrocortisone<br>
Less than 0.15 microgram gentamicin sulfate<br>
Less than 1 microgram ovalbumin<br>
Less than 50 micrograms formaldehyde<br>
Less than 50 micrograms sodium deoxycholate<br>
(no preservatives)<br><br>
The influenza viruses used are propagated in embryonated chicken eggs. Three strains are used: 1) A/New Caledonia/20/99 (H1N1), 2) A/New York/55/2004 (H3N2) (an A/California/7/2004-like strain), and 3) B/Jiangsu/10/2003 (a B/Shanghai/361/2002-like strain). The viruses are disrupted using detergent and inactivated with sodium deoxycholate and formaldehyde that leadis to the production of a “split virus.”<br><br>
…<br><br><a href="http://64.233.167.104/search?q=cache:p0Yg5kdtGtIJ:www.fda.gov/cber/label/hepbgsk013007LB.pdf+energix-b+label&hl=en&ct=clnk&cd=1&gl=us&client=firefox-a" target="_blank">Engerix-B</a> (Hepatitis B)<br><br><span style="text-decoration:underline;">Pediatric/Adolescent formulation</span><br>
10 micrograms hepatitis B surface antigen adsorbed on 0.25 mg aluminum as aluminum hydroxide<br>
4.5 mg sodium chloride<br>
0.49 mg disodium phosphate dehydrate (a buffer)<br>
0.352 mg sodium dihydrogen phosphate dehydrate<br><br><span style="text-decoration:underline;">Adult formulation</span><br>
20 micrograms hepatitis B surface antigen adsorbed on 0.5 mg aluminum as aluminum hydroxide<br>
9 ml sodium chloride<br>
0.98 mg disodium phosphate dehydrate<br>
0.71 mg sodium dihydrogen phosphate dehydrate<br>
No more than 5% yeast protein<br><br>
The virus is obtained by culturing genetically engineered <i>Saccharomyces cerevisiae</i> cells, which carry the surface antigen gene of the hepatitis B virus. Once purified, the antigen is adsorbed onto aluminum hydroxide.<br><br>
…<br><br><a href="http://64.233.167.104/search?q=cache:5irqjWvaeM4J:www.merck.com/product/usa/pi_circulars/r/recombivax_hb/recombivax_pi.pdf+recombivax+hb+label&hl=en&ct=clnk&cd=3&gl=us&client=firefox-a" target="_blank">Recombivax HB</a> (Hepatitis B)<br><br><span style="text-decoration:underline;">Pediatric/Adolescent Formulation</span><br>
5 micrograms hepatitis B surface antigen.<br>
Not more than 1% yeast protein but no detectable yeast DNA<br>
(no preservatives)<br><span style="text-decoration:underline;"><br>
Adult Formulation</span><br>
10 micrograms hepatitis B surface antigen<br>
Not more than 1% yeast proteins but no detectable yeast DNA<br>
(no preservatives)<br><span style="text-decoration:underline;"><br>
Dialysis Formulation</span><br>
40 micrograms hepatitis B surface antigen<br>
Not more than 1% yeast protein but no detectable yeast DNA<br>
(no preservatives)<br><span style="text-decoration:underline;"><br>
All formulations</span><br>
0.5 mg of aluminum<br><br><i>Cell cultures is performed on a recombinant strain of the yeast<br>
Saccharomyces cerevisiae</i> containing the gene for the adw subtype of HBsAg. <i>S. cerevisiae</i> is grown in a complex fermentation medium of an extract of yeast, soy peptone, dextrose, amino acids and mineral salts. The purified protein is treated with formaldehyde and coprecipitated with alum (potassium aluminum sulfate) to create the bulk vaccine adjuvanted with amorphous aluminum hydroxyphosphate sulfate.<br><br>
…<br><br><a href="http://64.233.167.104/search?q=cache:eek:pmh_np-pdQJ:www.fda.gov/cber/label/havgsk022106LB.pdf+havrix+label&hl=en&ct=clnk&cd=2&gl=us&client=firefox-a" target="_blank">Havrix</a> (Hepatitis A)<br><span style="text-decoration:underline;"><br>
Adult formulation</span><br>
Not less than 1440 EL.U viral antigen<br>
0.5 mg aluminum hydroxide<br>
0.5% (weight-to-volume) 2-phenoxyethanol (preservative)<br>
0.3% (weight-to-volume) amino acid supplement in a phosphate-buffered saline solution<br>
Not more than 0.1 mg per ml formalin<br>
Not more than 40 nanograms per ml of neomycin sulfate<br><span style="text-decoration:underline;"><br>
Pediatric formulation #1</span><br>
Not less than 360 EL.U (ELISA Units) viral antigen per 0.5 ml<br>
0.25 mg aluminum hydroxide<br>
0.5% (weight-to-volume) 2-phenoxyethanol (preservative)<br>
0.3% (weight-to-volume) amino acid supplement in a phosphate-buffered saline solution<br>
Not more than 0.1 mg per ml formalin<br>
Not more than 40 nanograms per ml of neomycin sulfate<br><br><span style="text-decoration:underline;">Pediatric formulation #2</span><br>
Not less than 720 EL.U viral antigen per 0.5 ml<br>
0.25 mg aluminum hydroxide<br>
0.5% (weight-to-volume) 2-phenoxyethanol (preservative)<br>
0.3% (weight-to-volume) amino acid supplement in a phosphate-buffered saline solution<br>
Not more than 0.1 mg per ml formalin<br>
Not more than 40 nanograms per ml of neomycin sulfate<br><br>
Strain HM175 of the hepatitis A virus is propagated in MRC-5 human diploid cells. The virus is inactivated with formalin.<br><br>
…<br><br><a href="http://64.233.167.104/search?q=cache:5SVRknBhHOUJ:www.fda.gov/cber/label/inflmed061703LB.pdf+flumist+label&hl=en&ct=clnk&cd=1&gl=us&client=firefox-a" target="_blank">FluMist</a> (influenza virus strains A and B live, intranasal)<br><br>
2003-2004 formulation<br>
Label appears to be incomplete<br><br>
106.5-7.5 TCID50 (median tissue culture infectious dose) of live attenuated influenza virus<br>
Less than 0.015 microgram per ml of gentamicin (limit of detection of assay)<br>
(no preservatives)<br>
0.47 mg buffer that contains sucrose, potassium phosphate, and monosodium glutamate<br><br>
Vaccine contains three influenza strains recommended by the U.S. Public Health Service for the 2003-2004 flu season: 1) A/New Caledonia/20/99 (H1N1), 2)<br>
A/Panama/2007/99 (H3N2) (A/Moscow/10/99-like), and 3) B/Hong Kong/330/2001. Each strain is attenuated and temperature-sensitives, with limited replication at body temperature.Each strain is a genetic reassortment of a master donor virus (A/Ann Arbor/6/60 and B/Ann<br>
Arbor/1/66) and a wild-type virus. The master donor viruses were developed in chick kidney cells. The three viruses were inoculated into chicken eggs. After incubation, the allantoic fluid is harvested and stabilized with a buffer that contains sucrose, potassium phosphate, and monosodium glutamate. The virus harvests are diluted with uninfected eggs to produce buld vaccine.
 

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<div style="margin:20px;margin-top:5px;">
<div class="smallfont" style="margin-bottom:2px;">Quote:</div>
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<div>Originally Posted by <strong>Crisstiana</strong> <a href="/community/forum/post/7959387"><img alt="View Post" class="inlineimg" src="/community/img/forum/go_quote.gif" style="border:0px solid;"></a></div>
<div style="font-style:italic;">A note on units:<br>
One microgram = one-millionth of a gram<br>
One nanogram = one-billionth of a gram<br>
One gram = 0.035 ounces<br>
Lf = limit flocculation, a unit of measure for toxins (I don't have conversion information)</div>
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I can only imagine which ingredient(s) contained in vaccines causes the death, demyelinating disorders, GBS, neurological disorders, screaming syndrome . . . .<br><br>
FTR, you can very easily see the ingredient information right in the very first paragraph of the product insert: <a href="http://www.vaccinesafety.edu/thi-table.htm" target="_blank">http://www.vaccinesafety.edu/thi-table.htm</a><br><br>
Click on "brand name" and it will open up to the product insert.
 

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Discussion Starter #3
I included the note on units because I know many people outside of the sciences are unfamiliar with the far ends of the metric system. Even folks who may have taken lab-based classes may not have encountered something like a nanogram because it is such a small unit.<br><br>
And, yes, I know this information is available in the inserts. This is why I mention that and provide a link to each insert. But it is a pain to flip through individual inserts, so I thought it would be helpful to pull the information together. If you find it useful, as I do, use it. If not, don't.
 

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<div style="margin:20px;margin-top:5px;">
<div class="smallfont" style="margin-bottom:2px;">Quote:</div>
<table border="0" cellpadding="6" cellspacing="0" width="99%"><tr><td class="alt2" style="border:1px inset;">
<div>Originally Posted by <strong>Crisstiana</strong> <a href="/community/forum/post/7959671"><img alt="View Post" class="inlineimg" src="/community/img/forum/go_quote.gif" style="border:0px solid;"></a></div>
<div style="font-style:italic;">I included the note on units because I know many people outside of the sciences are unfamiliar with the far ends of the metric system.</div>
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Yes, many are indeed unfamiliar with the metric system - namely the FDA, CDC and the pediatrician members of the AAP. That surely must be the reason why infants were getting 67.5 micrograms of thimerosal at every visit every two months before parents of mercury poisoned children had to point it out to those smart, scientifically-minded doctors.<br><br><div style="margin:20px;margin-top:5px;">
<div class="smallfont" style="margin-bottom:2px;">Quote:</div>
<table border="0" cellpadding="6" cellspacing="0" width="99%"><tr><td class="alt2" style="border:1px inset;">
<div>Originally Posted by <strong>Crisstiana</strong> <a href="/community/forum/post/7959671"><img alt="View Post" class="inlineimg" src="/community/img/forum/go_quote.gif" style="border:0px solid;"></a></div>
<div style="font-style:italic;">If you find it useful, as I do, use it. If not, don't.</div>
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This will be useful to many parents. It's nice to see all the crap contained in vaccines in one place.
 

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Interesting post, thanks for putting the ingredients all in one place. <img alt="" class="inlineimg" src="http://www.mothering.com/discussions/images/smilies/smile.gif" style="border:0px solid;" title="smile"><br><br>
I wonder. How much botulism does it take to spoil the beans? Just 1 spore? 2?
 

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Long Island, we have become heavily biased towards vaccine reactions in lieu of high endemnicity of diseases and inadequate medical care. Pneumonia, Subacute sclerosing panencephalitis (SSPE), Subacute measles encephalitis (SME), Acute measles encephalitis, Otosclerosis, Autoimmune disease, Aseptic meningitis, Encephalitis, Orchitis, Sterility (males), Pancreatitis, Deafness, Congenital abnormalities, Encephalitis, Thrombocytopenia with hemorrhagic manifestations, Liver failure, Screaming/Crying for days and of course Death are just a short list of some of the effects of <span style="text-decoration:underline;">natural disease infection</span>. Life is full of risks, we have to choose the foreseeable ones we can live with.<br><br>
SM
 

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<div style="margin:20px;margin-top:5px;">
<div class="smallfont" style="margin-bottom:2px;">Quote:</div>
<table border="0" cellpadding="6" cellspacing="0" width="99%"><tr><td class="alt2" style="border:1px inset;">
<div>Originally Posted by <strong>NatureMama3</strong> <a href="/community/forum/post/7960542"><img alt="View Post" class="inlineimg" src="/community/img/forum/go_quote.gif" style="border:0px solid;"></a></div>
<div style="font-style:italic;">Interesting post, thanks for putting the ingredients all in one place. <img alt="" class="inlineimg" src="http://www.mothering.com/discussions/images/smilies/smile.gif" style="border:0px solid;" title="smile"><br><br>
I wonder. How much botulism does it take to spoil the beans? Just 1 spore? 2?</div>
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I realize that you are in part drawing an analogy, but the answer is that just a few nanograms of the botulinum toxin can cause illness (it is among the most potent toxins known). For that reason, the AAP recommends that honey, which can contain botulism spores, not be given to any child under the age of 1 year. Unless there is clear evidence of its safety, I think it would be reasonable for a parent to apply the same thinking to substances such as mercury and decide not to vax. But the decisions surrounding vaxes are complex and involve risk-benefit balancing that is unique to each person. I think it may also be reasonable for a parent to examine some childhood vaxes, the illnesses they aim to prevent, and decide to vax. I just hope that the decision - whatever the result - is as well-informed as possible. Unfortunatley, the CDC does not make parents's jobs any easier as it does not assemble all the information in one location. It should do that and more.
 

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<div style="margin:20px;margin-top:5px;">
<div class="smallfont" style="margin-bottom:2px;">Quote:</div>
<table border="0" cellpadding="6" cellspacing="0" width="99%"><tr><td class="alt2" style="border:1px inset;">
<div>Originally Posted by <strong>Crisstiana</strong> <a href="/community/forum/post/7961133"><img alt="View Post" class="inlineimg" src="/community/img/forum/go_quote.gif" style="border:0px solid;"></a></div>
<div style="font-style:italic;">the AAP recommends that honey, which can contain botulism spores, not be given to any child under the age of 1 year.</div>
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No honey gals!!! The AAP says it could harm your babies. <img alt="" class="inlineimg" src="http://www.mothering.com/discussions/images/smilies/nono.gif" style="border:0px solid;" title="nono"><br><br>
But thimerosal is not dangerous though. The AAP says you can go ahead and vax your 6 month old with thimerosal-containing influenza vaccine. That would be 12.5 micrograms of thimerosal in each dose for infant-3 years of age and 25 micrograms in each dose for children 3+ years.<br><br>
And millions of infants and children will have the added bonus of getting TWO doses of thimerosal-containing influenza vaccine - the first dose and then another dose 30 days later.
 

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Someone that I know of just suffered a Unexplained death of her child in march a lil boy a 2 wks after recieving his vaccinations which were dpt -he fell out of bed & the brain looked like a brain from shaken baby syndrome.
 

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<div style="margin:20px;margin-top:5px;">
<div class="smallfont" style="margin-bottom:2px;">Quote:</div>
<table border="0" cellpadding="6" cellspacing="0" width="99%"><tr><td class="alt2" style="border:1px inset;">
<div>Originally Posted by <strong>Crisstiana</strong> <a href="/community/forum/post/7961133"><img alt="View Post" class="inlineimg" src="/community/img/forum/go_quote.gif" style="border:0px solid;"></a></div>
<div style="font-style:italic;">I realize that you are in part drawing an analogy, but the answer is that just a few nanograms of the botulinum toxin can cause illness (it is among the most potent toxins known). For that reason, the AAP recommends that honey, which can contain botulism spores, not be given to any child under the age of 1 year. Unless there is clear evidence of its safety, I think it would be reasonable for a parent to apply the same thinking to substances such as mercury and decide not to vax. But the decisions surrounding vaxes are complex and involve risk-benefit balancing that is unique to each person. I think it may also be reasonable for a parent to examine some childhood vaxes, the illnesses they aim to prevent, and decide to vax. I just hope that the decision - whatever the result - is as well-informed as possible. Unfortunatley, the CDC does not make parents's jobs any easier as it does not assemble all the information in one location. It should do that and more.</div>
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I think that's a very reasonable position, and I totally agree.<br><br>
On this:<br><div style="margin:20px;margin-top:5px;">
<div class="smallfont" style="margin-bottom:2px;">Quote:</div>
<table border="0" cellpadding="6" cellspacing="0" width="99%"><tr><td class="alt2" style="border:1px inset;">But the decisions surrounding vaxes are complex and involve risk-benefit balancing that is unique to each person.</td>
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A big, big part of the problem is that a lot of the necessary information to make the "right" choice is totally unknown. Simple things like "How much protection do the first 2 doses of the DTaP give to my very pertussis vunerable newborn"? And "How neurotoxic is the DTaP with it's bacterial toxins and aluminum adjuvant?"<br>
So whatever you choose, you're still making an intuitive guess.<br><br>
I guess that's why I'm kind of moderate on the whole thing. I'm not going to judge someone else's guess.
 

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Science Mom wrote:
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<div class="smallfont" style="margin-bottom:2px;">Quote:</div>
<table border="0" cellpadding="6" cellspacing="0" width="99%"><tr><td class="alt2" style="border:1px inset;">we have become heavily biased towards vaccine reactions in lieu of high endemnicity of diseases and inadequate medical care.</td>
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Endemnicity was a new word for me, so I headed for my trusty old dictionary.<br><br>
It is the adverbial form of endemic, and should be spelled endemicity.<br><br>
Endemic, according to my dictionary is: "constantly present in a particular region: said of a disease that is generally under control: cf. EPIDEMIC"<br><br>
So, apparently, endemic is not the right description for what has been going on with pertussis--the right description would be: epidemic!
 

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I'm feeling picky about language tonight. I don't think that damage that follows a natural disease process should be called a reaction. Side-effect doesn't seem to fit either.<br><br>
Went and searched the NLM medical encyclopedia. The right word is <span style="font-size:large;">complications <img alt="" class="inlineimg" src="/img/vbsmilies/smilies/fever.gif" style="border:0px solid;" title="Fever">:</span>
 

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A "quick list" for routinely recommended <b><span style="color:#0000FF;">aluminum</span></b>-containing vaccines:<br><br>
Hepatitis A<br>
Hepatitis B<br>
Gardasil (HPV)<br>
DTaP (diptheria, tetanus, pertussis)<br>
Prevnar (pneumococcal)
 

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A "quick list" of the routinely recommended vaccines for children/adults containing <b><span style="color:#0000FF;">aborted fetal tissue</span></b>:<br><br>
Vaqta/Havrix <b>(Hepatitis A)</b><br>
Twinrix <b>(Hep A/Hep B)</b><br>
M-M-R-II <b>(MMR)</b><br>
ProQuad <b>(MMR + chicken pox)</b><br>
Varivax <b>(chicken pox)</b><br>
Zostavax <b>(shingles)</b>
 

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<table border="0" cellpadding="6" cellspacing="0" width="99%"><tr><td class="alt2" style="border:1px inset;">Fluzone (influenza)<br><br>
45 micrograms hemagglutinin, in the recommended ratio of 15 g HA each, representative of the following three prototype strains: A/New Caledonia/20/99/IVR-116 (H1N1), A/New York/55/2004/X-157 (H3N2) (an A/California/7/2004-like strain) and B/Jiangsu/10/2003 (a B/Shanghai/361/2002-like strain)<br>
0.05% gelatin (stabilizer)<br><b>25 micrograms of <span style="color:#FF0000;">aluminum</span> per dose from a 5 ml via</b>l (the 0.25 ml prefilled syringe dose for 6-25 months of age, the 0.5 ml prefilled dose for 26 months and older, and the 0.5 ml vial for 36 months of age and older do not contain a preservative and thimerosal is not used in the manufacturing process of these preparations)</td>
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Did you mean to say "mercury" there instead of "aluminum"?
 

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You are correct, Mamakay. I changed it to read "mercury". Thanks for catching that. <img alt="" class="inlineimg" src="http://www.mothering.com/discussions/images/smilies/smile.gif" style="border:0px solid;" title="smile">
 

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<div style="margin:20px;margin-top:5px;">
<div class="smallfont" style="margin-bottom:2px;">Quote:</div>
<table border="0" cellpadding="6" cellspacing="0" width="99%"><tr><td class="alt2" style="border:1px inset;">
<div>Originally Posted by <strong>LongIsland</strong> <a href="/community/forum/post/7985014"><img alt="View Post" class="inlineimg" src="/community/img/forum/go_quote.gif" style="border:0px solid;"></a></div>
<div style="font-style:italic;">A "quick list" for routinely recommended <b><span style="color:#0000FF;">alumimun</span></b>-containing vaccines:<br><br>
Hepatitis A<br>
Hepatitis B<br>
Gardasil (HPV)<br>
DTaP (diptheria, tetanus, pertussis)<br>
Prevnar (pneumococcal)</div>
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<br>
Sorry LI, but it is spelled aluminum! You were probably too busy with the blue to pay attention.<br><br>
Going off spell check duty--you all are on your own now!<img alt="" class="inlineimg" src="/img/vbsmilies/smilies/duck.gif" style="border:0px solid;" title="Duck">:
 
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