I have both and what I would call the biggest difference is that with the MT, you can adjust it better to your body and to your baby. You can make the body smaller so baby gets to see more, or carry it higher up your back so they can look over your shoulder, tie the straps tighter so that baby is snug to your body, whereas with the Ergo it's all a bit more loose, more of a one size-fits all (despite the straps you can tighten). As far as comfort, I personally favor the Ergo for a backcarry with DD (almost 2). DS is still very small so I use the Mei Tai as a front carry with him and that is very comfortable too.