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Discussion Starter · #1 ·
<b>hMPV/PIV-3 vaccine</b><br><br><i>MedImmune is working on a vaccine that could potentially prevent human metapneumovirus (hMPV) and parainfluenzavirus type 3 (PIV-3). <b>These viruses, along with respiratory syncytial virus (RSV) are among the most commonly occurring respiratory viruses of childhood, causing bronchitis, bronchiolitis, croup, cough, fever and pneumonia.</b><br><br>
hMPV is a newly discovered virus believed to be a common cause of serious lower respiratory tract infections in young children. Early epidemiology studies indicate that outbreak patterns of hMPV are similar to those of other respiratory infections, occurring in annual epidemics that peak during the fall and winter months. <b>It is believed that by five years of age nearly all children will have been infected with hMPV.</b> The clinical symptoms of hMPV range from mild respiratory problems to severe cough, bronchiolitis and pneumonia.<br><br>
PIV-3 infects infants, children and adults, primarily during the spring and summer months. In the United States, at least 60 percent of children are infected by the time they reach two years of age and 80 percent by age four, with symptoms lasting from three to eight days. While the majority of PIV-3 infections are mild to moderate, lower respiratory tract disease due to PIV-3 is responsible for as many as 50,000 hospitalizations annually in the United States. There is currently no available PIV-3 vaccine or therapeutic.<br><br>
In addition to this vaccine tarketing both hMPV and PIV-3, MedImmune is also working to develop antibodies that may have the potential to prevent hMPV infection.</i><br><br><a href="http://www.medimmune.com/pipeline/index.asp" target="_blank">http://www.medimmune.com/pipeline/index.asp</a>
 

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Discussion Starter · #2 ·
<a href="http://jcm.asm.org/cgi/content/full/43/3/1213" target="_blank">http://jcm.asm.org/cgi/content/full/43/3/1213</a>
 

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Discussion Starter · #3 ·
<b>What is hMPV?</b><br>
Most parents have never heard of it – yet. Human metapneumovirus (hMPV) is a respiratory virus first discovered by scientists in the Netherlands in 2001. It can cause pneumonia, bronchiolitis, and-flu-like illness. It seems to behave similarly to another virus called RSV (respiratory syncytial virus).<br><br>
Testing showed that nearly all children in the Netherlands had been infected with hMPV by age five. The virus has since been found in Australia, Canada, and Britain. Is it in the United States? Hundreds of children with respiratory infections were screened at Yale University, and the results were published in the June 2003 issue of Pediatrics. More than 6 percent of children screened showed laboratory evidence of hMPV infection.<br><br>
Coughing, runny nose, fever, and wheezing were the most common symptoms. About 1/3 of the children required supplemental oxygen. Each year in the United States more than 150,000 young children are hospitalized for bronchiolitis – and that number has been increasing steadily.<br><br>
Often the virus causing the bronchiolitis is unknown, with negative tests for RSV, influenza, parainfluenza, and adenovirus. Perhaps hMPV is already a major cause of serious respiratory infections on three continents. It’s something we’ll need to pay attention to in the years to come.<br><br><a href="http://www.drgreene.com/21_1621.html" target="_blank">http://www.drgreene.com/21_1621.html</a>
 

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So when you don't know anything about it, then you don't worry about it. Once you find it, find the vaccine, and work people up to a new 50,000 cases in hospital every year.<br><br>
Oh yay. Don't you wonder how you even survived past the cot stage?
 

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URl for first post:<br><br><a href="http://www.medimmune.com/pipeline/hMPVPIV3vaccine.asp" target="_blank">http://www.medimmune.com/pipeline/hMPVPIV3vaccine.asp</a>
 

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In a cached item off a board no longer in existence I found this from a virologist:
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<table border="0" cellpadding="6" cellspacing="0" width="99%"><tr><td class="alt2" style="border:1px inset;">The human pneumoviruses and the metapneumoviruses are ubiquitous respiratory pathogens. Infection occurs in infancy and early childhood, but does not confer prolonged immunity. In the case of respiratory syncytial virus (a pneumovirus) it has been estimated that reinfection occurs on average every 36 months. The outcome of infection can be serious in infancy (bronchiolitis) and in the elderly (pneumonia), At other ages infection is usually asymptomatic or mild URTI.</td>
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So tell, me, was all the pneumonia ascribed to influenza, influenza? or something else?<br><br>
We seem to have shifting goalposts all the time.....
 

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I can see the value of this for preemies that have to go into daycare at a young age, but that's about it. What's going to happen to everyone's health if kids don't get sick anymore?
 

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Where does the RSV come from? Where did it originate? Is it at all possible that this is a possible contaminent of vaccines? I had never heard of this until after 1995, may have been around, but it wasn't as common as it is today. Just wondering what the possibilities may be.<br><br>
Looks like another hib/prevnar type vax in the works, and if you can avoid it before your child starts school, it will be another that is just "recommended", not required, but most peds will operate as if it is mandated and will not give parents a choice or informed consent options.
 

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Discussion Starter · #10 ·
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<div>Originally Posted by <strong>suschi</strong></div>
<div style="font-style:italic;">Looks like another hib/prevnar type vax in the works, and if you can avoid it before your child starts school, it will be another that is just "recommended", not required, but most peds will operate as if it is mandated and will not give parents a choice or informed consent options.</div>
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Hib is actually already mandatory for preschool in almost every state. Although the requirement is typically <span style="text-decoration:underline;">one dose</span> for a child after 15 months of age.<br><br>
Pneumoccocal is slowly becoming mandatory for preschool as well.
 

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We don't do preschool, so it was never "required" for my children (hib or prevnar) but certainly one would get the impression it was.<br><br>
If your child does not attend daycare or preschool, and you can manage to avoid these vaccines, they will not be required for Kindergarten entry in most states. I should have been clearer on the previous post.<br><br>
I believe this new one in the works will follow suit.
 

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Discussion Starter · #12 ·
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<div>Originally Posted by <strong>suschi</strong></div>
<div style="font-style:italic;">it was never "required" for my children (hib or prevnar) but certainly one would get the impression it was.</div>
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<img alt="" class="inlineimg" src="http://www.mothering.com/discussions/images/smilies/nod.gif" style="border:0px solid;" title="nod"><br>
There are no states requiring Hib for kindergarten entry.<br><br>
This is why it's important, particularly those selectively/delaying, to know their minimum state requirements since requirements are different for daycare/preschool and K entry.<br><br>
For example, in most states, a child entering preschool would only need one dose of Hib and no Prevnar and possibly no varicella.
 
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