When she was first born I had to wake her up to feed her most of the time- but yes, she fell into a schedule. So I just started waking her up when I wanted her schedule to be- every day at 6am, that way I knew when the feedings would be and they would be the same every day. It didn't always work- sometimes she would wake up at 5am, so I worked w/ that. Now she goes every 4 hours and I still have to wake her up half the time.
I will say though that she has been an easy baby. She is 3 months old now- born April 1.
I did use Babywise w/ my older kids-- not a strict schedule, and I wasn't rigid, "cruel", etc. Naomi is definitely more predictable than they were schedule-wise.
I think you can schedule babies w/o CIO- if you get them in a pattern. THey need alot of sleep and I think schedules let them have the amount of sleep they need.
As far as comfort- I give her plenty, someone is always talking to her, holding her, snuggling, etc. and she nurses for a good 30 minutes if not longer. I make it more of a point, because she is so good/easy I don't want her to be forgotten about.