<p>In the INV thread I noticed measles was being discussed and someone mentioned parents in areas where there are current outbreaks panicking and wanting young babies (4 mos or so) to be vaccinated with MMR.</p>
<p> </p>
<p>I understand that it's mainly the efficacy concerns and not safety concerns that are the reason for the delay for MMR to 15 mos. Maternal antibodies can fight the vaccine virus, and interfere with the production of antibodies in younger babies.</p>
<p> </p>
<p>The <a href="https://www.merck.com/product/usa/pi_circulars/m/mmr_ii/mmr_ii_pi.pdf" target="_blank">vaccine insert</a> says this:</p>
<div>Infants Between 6 to 12 Months of Age</div>
<div>Local health authorities may recommend measles vaccination of infants between 6 to 12 months of age in outbreak situations. This population may fail to respond to the components of the vaccine. Safety and effectiveness of mumps and rubella vaccine in infants less than 12 months of age have not been established. The younger the infant, the lower the likelihood of seroconversion (see CLINICAL PHARMACOLOGY). Such infants should receive a second dose of M-M-R II between 12 to 15 months of age followed by revaccination at elementary school entry.</div>
<div>Unnecessary doses of a vaccine are best avoided by ensuring that written documentation ofvaccination is preserved and a copy given to each vaccinee's parent or guardian."</div>
<div> </div>
<p>Does anyone know more about this? Is there a safety issue?</p>
<p>Know any examples where children under 12 mos have been immunized during outbreaks?</p>
<p> </p>
<p>I understand that it's mainly the efficacy concerns and not safety concerns that are the reason for the delay for MMR to 15 mos. Maternal antibodies can fight the vaccine virus, and interfere with the production of antibodies in younger babies.</p>
<p> </p>
<p>The <a href="https://www.merck.com/product/usa/pi_circulars/m/mmr_ii/mmr_ii_pi.pdf" target="_blank">vaccine insert</a> says this:</p>
<div>Infants Between 6 to 12 Months of Age</div>
<div>Local health authorities may recommend measles vaccination of infants between 6 to 12 months of age in outbreak situations. This population may fail to respond to the components of the vaccine. Safety and effectiveness of mumps and rubella vaccine in infants less than 12 months of age have not been established. The younger the infant, the lower the likelihood of seroconversion (see CLINICAL PHARMACOLOGY). Such infants should receive a second dose of M-M-R II between 12 to 15 months of age followed by revaccination at elementary school entry.</div>
<div>Unnecessary doses of a vaccine are best avoided by ensuring that written documentation ofvaccination is preserved and a copy given to each vaccinee's parent or guardian."</div>
<div> </div>
<p>Does anyone know more about this? Is there a safety issue?</p>
<p>Know any examples where children under 12 mos have been immunized during outbreaks?</p>
