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<div>Originally Posted by <strong>mamakay</strong> <a href="/community/forum/post/10348563"><img alt="View Post" class="inlineimg" src="/community/img/forum/go_quote.gif" style="border:0px solid;"></a></div>
<div style="font-style:italic;">I'm not sure what the WHO guys are talking about there...</div>
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I'm a little fuzzy on that too, but I doubt it was a typo. I can't access the first two studies, so I don't know what the specifics of those were. I might try to sell you the possibility that they <i>didn't</i> show increasing seropositivity with advancing age, and that the Metzkin & Regev study was tacked on for balance, but I don't see myself being able to muster enough enthusiasm to be very convincing. The authors of the WHO article express concerns about some of the assay methodology used, indirect (or "passive") hemagglutination in particular, and they also take a quite reserved approach where the implications on immunity are concerned even when antibodies are detected, especially at very low titers.<br><br>
They state with some confidence: "<i>A small amount of tetanus toxin, although enough to cause the disease, is insufficient to stimulate antibody production"</i>. I'm looking for some further reading on that. It seems like it would be simple enough to test for antibodies following infection, and it's bound to have been done jillions of times, but I browsed through their entire reference list, and if there's a study that used immunocompetent humans, I missed it. Are they extrapolating that from vaccine studies?<br><br><div style="margin:20px;margin-top:5px;">
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<table border="0" cellpadding="6" cellspacing="0" width="99%"><tr><td class="alt2" style="border:1px inset;">I wonder if anyone's ever looked to see if folks are ever immune to the actual bacteria. Not just the toxin, but the actual bacterial antigens...</td>
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Considering how little bacteria it takes to produce a lethal dose of toxin, it doesn't seem likely, but maybe, I guess.
 
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