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<a href="http://www.boston.com/yourlife/health/diseases/articles/2007/04/24/in_wake_of_vaccine_new_pneumonia_strains_emerge/" target="_blank">http://www.boston.com/yourlife/healt...trains_emerge/</a><br><br>
I wish I had known all of this before my kids had the prevnar shots! The researchers are saying they expected this all along--that new strains would take place of the ones protected against in the vaccine. Instead of suggesting that perhaps it wasn't such a great idea, they are now developing a 13-strain vaccine instead.
 

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They're not just developing a PCV13...it's in phase III clinical trials now with an ETA of 2010. There's are also Menactra (the meningococcal version of prevnar) in phase III as we speak, so that'll be an additional 10 strains of bacterial flora eliminated from the population at once, making room for god-knows-what to move in next.
 

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<a href="http://clinicaltrials.gov/ct/search;jsessionid=95D2D04E7CDCBE4D1B2550C08C286857?term=Prevnar&submit=Search" target="_blank">http://clinicaltrials.gov/ct/search;...&submit=Search</a>
 

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<div>Originally Posted by <strong>mamakay</strong> <a href="/community/forum/post/7942418"><img alt="View Post" class="inlineimg" src="/community/img/forum/go_quote.gif" style="border:0px solid;"></a></div>
<div style="font-style:italic;">They're not just developing a PCV13...it's in phase III clinical trials now with an ETA of 2010. There's are also Menactra (the meningococcal version of prevnar) in phase III as we speak, so that'll be an additional 10 strains of bacterial flora eliminated from the population at once, making room for god-knows-what to move in next.</div>
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omg...that is frightening. how can these people not realize what they are doing?? or do they, but they are just so greedy that the money is all that matters to them.... this is insanity!
 

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<div>Originally Posted by <strong>nataliachick7</strong> <a href="/community/forum/post/7942463"><img alt="View Post" class="inlineimg" src="/community/img/forum/go_quote.gif" style="border:0px solid;"></a></div>
<div style="font-style:italic;">omg...that is frightening. how can these people not realize what they are doing?? or do they, but they are just so greedy that the money is all that matters to them.... this is insanity!</div>
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I know.<br>
On the bright side...it looks like they're now (seven years after introducing Prevnar into the mass immunization program) going to start trying to figure out what the deal is.<br><br><a href="http://clinicaltrials.gov/ct/show/NCT00294021?order=25" target="_blank">http://clinicaltrials.gov/ct/show/NCT00294021?order=25</a><br><br>
On Native Americans living on reservations, it appears.<br><br><img alt="" class="inlineimg" src="http://www.mothering.com/discussions/images/smilies/irked.gif" style="border:0px solid;" title="irked">:
 

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AHHHHHHHHHHHHHHHHHHHH!!! Makes me crazy!<br><br>
Mamakay...you always have such great info though to keep us all in the loop...thank you for always posting your links/sources. I've been able to come across some info I wouldn't have found on my own.
 

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There have been some studies on the effect of Prevnar on disease-causing serotypes, and I know others are ongoing to monitor any changes possibily due to the vaccine. One possible positive is that the vaccine may be effective against more than the 7 serotypes due to subgroup cross-protection (e.g, 6B is included in the vaccine, but it appears that the vax may confer some protection against 6A). Here's one study, from the Journal of Antimicrobial Chemotherapy (2002), "<a href="http://jac.oxfordjournals.org/cgi/content/abstract/50/suppl_3/13" target="_blank">Antimicrobial susceptibility and pneumococcal serotypes</a>" (full text is available for free via link). It basically stresses the importance of serotype monitoring, especially with regard to penicillin-resistance, given the effect of Prevnar.
 

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But even if there's a cross-reactive protection, if it reduces or eliminates carriage, it's still going to result in more serotype replacement. They could add all the serotypes in Pneumovax23 to the PCV, and it still wouldn't be an end to "bacterial infections", because whatever emerges next will still act like a pathogen when the conditions are right. I guess in theory we could hit some magical point where the balance was perfect and everything left was realtively mild, but I'm not seeing it as terribly likely, and it's equally likely that something worse than anything that came before could emerge.<br>
All the conjugate vaccines...Hib, PCV, and MCV have resulted in some form of serotype replacement. Sometimes there's a delay, but it always happens.<br>
This whole things seems terribly....ecologically unsound...to me.
 
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