Mothering Forum banner
1 - 7 of 7 Posts

·
Registered
Joined
·
1,818 Posts
Discussion Starter · #1 ·
I know this will not make a difference in the outcome, but what do you ladies think about this?

DW has cancer and the chemo will likely put her into menopause. So before starting the chemo, we opted to do one round of IVF in hopes of securing some eggs to be frozen as embryos. DW took Gonal-F and Repronex.

After 5 days of Gonal-F alone, her estrogen level was 116. They then put us on Repronex. So after 7 days Gonal- F and 2 days Repronex, estrogen was 448. After 8 days Goanl-F and 3 days Repronex, estrogen was 548. 6 follicles at this point. 2 big ones and 4 follicles between 4 ½ and 9.

This all happens Monday:

After 10 days of Gonal-F and 5 days of Repronex, we go in for another blood draw and US. One follicle is mature and five are in the 8x9 range. Nurse draws the blood and says, "So you guys started the Cetrotide, right?" We said no, we were never told to do so yet. She said, Oh, you will probably start tonight.

She called back a few hours later and told us the retrieval was off. DW's estrogen dropped from 548 on Saturday to 377 on Monday. So it is all done, finished. No chance for DW to ever have biological children.

We think they forgot to tell us to start the Cetrotide, which prevents ovulation, and DW ovulated naturally. We looked up information about Cetrotide last night and found that most women must take it after 4-6 days of stims, but never later than 8 days after starting the stims. We took them for 10 days. The way the nurse asked if we were taking it makes us really question if they did not goof.

Furthermore, DW kept saying all weekend that her ovaries felt funny, like they do when she ovulates.

Should we question the doctor? If so, what do we say? We do not know what to do. I think we would like to know if there was something wrong with DW or if they screwed up with the meds.

Sorry this is so long.
 

·
Registered
Joined
·
400 Posts
Hmmmm, i don't know. Every RE has such different protocals. Did they give it all to you in a calender chart or were they telling you (then i would think it very likely they forget to tell you about a med.) You would need to get your chart and have another RE look at it and tell you their opinion. For a first IVF w/o known problem our RE uses Lupron (all the same drug category as Cetrotide), but in my DP's second IVF in order to increase egg production he didn't use the Lupron. When we asked about ovulation he said he was monitoring close enough and wouldn't let her ovulate before the HCG shot. She had several seemingly growing follicles implode during a medicated IUI and we never really got a clear answer why just sometimes the hormones cause these things to happen. But definitely get a second opinion if that will give you peace!

Thinking of you guys...
 

·
Registered
Joined
·
3,285 Posts
Oh, I am so sorry. ITA with the pp - get a second opinion. If there was a mistake made, perhaps it can be rectified somehow, though I know the $$ is nothing compared to what you have lost. But at the least, when it is time to go for your next step in building your family, you will have a better idea of whether or not you want to stay with this clinic.

(((Hugs))) to you both. Please keep us posted. I know everyone hear will be anxious to hear about your next step(s) in your journey.
 

·
Registered
Joined
·
300 Posts
I am sorry. I did fertility treatments with injectibles but we were not at the IVF stage yet, pretty close, but I do know that my RE doesn't use lupron or anything like that to prohibit premature ovulation unless you have ovulated early on a past cycle. Usually the first cycle is like a practice cycle to see how you respond to meds. The first time I was on injections, I gave myself shots for over two weeks and I ended up without any eggs in that cycle, my estrogen never went past 62. I can tell your dw did not have enough eggs to even continue on with IVF which probably had to do with the dosage of stims or even the med combo. It would have been enough for an IUI but clearly pregnancy is not a good idea at this time. How much was she supposed to take? They estimate every 200 points of estrogen for one mature egg so she had like almost 2 which is not enough for an IVF because some deteriorate in the process of removal.

Plus generally speaking while taking the stim drugs, the meds are supposed to take over your whole hormonal system and not ovulate until you take a trigger shot to start ovulation. But sometimes women do ovulate and there isn't a way for them to predict it without like a practice cycle. I'm sure that if you went on to another cycle they would have it figured out better.

In my opinion they didn't make a mistake because they really are not sure how each woman will respond to the stimulation. You could get a second opinion if it makes you feel better, but every fertility specialist has their own protocols like the pp said. You could just ask your fert doc why didn't it work and why did dw ovulate early, could we have prevented it, etc? My RE's office has been very helpful and informative every time a cycle failed.

Is there any way that your wife could do radiation instead of chemo? Because I heard of another lady doing that and it didn't harm her eggs and it gave her time to have eggs retrieved. I am trying to remember the magazine I read about this young woman who has an organization that helps women who have cancer and are trying to preserve her fertility. I will look around and post back later. Anyway, they thought that she would go into menopause after having radiation and chemo as she had cancer twice, but she was still fertile afterwords and got pregnant through IVF. Maybe talk with your oncologist about trying another cycle.

Yes please post back and let us know how things are. I wish the best for you and for your wife healing.
 

·
Registered
Joined
·
4 Posts
Hi! I lurk here often and happened upon your post. I am an IVF nurse and also the mother of a 2 year old daughter that I am raising with my sweet wife, Priscilla.

Your office messed up big time. They obviously forgot to add the Cetrotide and the resulting ovulation by your DW was 100% avoidable. I hate to rub salt in the wound but I am so angry for you. It is much more appalling since this wasn't just a run of the mill attempt at pregnancy. It was a one shot deal. I am so upset for you.

You need answers. You need to speak to the doctor. Please, please email me anytime with questions. I don't usually lurk on this forum but obviously did today for a reason.

[email protected]

Hugs!!!
Michelle
 

·
Registered
Joined
·
486 Posts
I'm so sorry to read that they probably screwed up. I was on a different cocktail for my IVF so I can't say whether what happened was right or not, but I can tell you that my clinic's personnel sat down with me beforehand to detail out, step by step, day by day, exactly what drugs would be given when (with hedge room for corrections to be made along the way as determined by hormone levels, of course). I had a sheet that told me all about what would happen when and why, what things did, etc.

Your clinic should have empowered you with that knowledge up front so if an error occurred, you could say, "Excuse me but shouldn't we be on drug X by now?" or "And we start drug Y tomorrow, right?"

I'm sorry that this information is too late for you, but hopefully anyone else reading will know in advance that this is something to expect of a clinic.

*big hugs*
 
1 - 7 of 7 Posts
Top