I am on progesterone shots through week ten of my pregnancy because I conceived through IVF, and the clinic takes no chances. Also, the meds throw your system off enough that it is a good idea to supplement. At first I felt some minor side effects from them - nausea mostly, and a little constipation, both of which quicky disappeared when the HCG levels started rising. Other than the fact that the daily shot is a pain in the butt - pun very much intended <img alt="" class="inlineimg" src="http://www.mothering.com/discussions/images/smilies/lol.gif" style="border:0px solid;" title="lol"> - I really don't notice the supplements in my life.<br><br>
I know that there are vaginal progesterone suppositories you can also take. I believe they are less money than the shots, but, imo, they are a heck of a lot more hassle. Imagine having to do a yeast infection medication every night for weeks on end. The one cycle I used them I was sore and irritated and they make a huge mess. When given a choice the next cycle, I chose the shot. But that is just me. Also, now that my pg is confirmed, the clinic is going to put me on time release progesterone, which is one shot per week. I did that with dd, and it worked beautifully. Again, imo far less hassle than the suppositories.<br><br>
Ok, that is about all I know. I do think there are other forms of supplementation out there, but I have not had to learn about them. I know there are other ladies on this board who are supplementing, so maybe they can jump in and fill in my gaps.