I work from home with my 6mo, but it's basically like working in an office because I have to clock in and clock out. What works for us is changing activities every 15-20 minutes. Nakey butt time can buy me a good half hour, she loves wiggling around on a blanket on a diaper naked. We also take breaks, I don't work full time, so this seems to be okay. Here are some things we do, about 20 mins each
Lay on the bed next to me with a toy
Nakey butt time
Eat
Sit on my lap while I type (this slows me down, so I try and only do it while I"m proofing)
Sit in the boppy with toys
Lay on the ground on a blanket (just a change in scenery is nice)
On my back in the Ergo (and she could go on my back starting at about 4 months)
Then we take a walk every day, and every hour I get up for 10 minutes and we do stuff that isn't on the computer. She takes good naps during the day and sleeps less at night.
HTH
Cara