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So just how do they determine what the time frame should be between shots? What studies are done that show 2 months is good for the first round and that longer between shots would reduce any benefit of the first shot? Is it purely a cumulative effects or an "onslaught" on the immune system? If you delay longer than recommended between shots, does it reduce the efficacy of the first one? I am primarily talking about the first 2,4,6 months series.
 

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I think it's more of a wild guess than an exact science.<br><br>
I get the impression that the 2,4,6 month schedule was just sort of arbitrarily chosen and tested, and found to work ok.<br><br>
I know they used to start the DTaP series at 3 months and bumped it back to 2 because infants were still dying from pertussis, but changing it from 3 to 2 didn't end up helping at all for some reason.
 
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