So just how do they determine what the time frame should be between shots? What studies are done that show 2 months is good for the first round and that longer between shots would reduce any benefit of the first shot? Is it purely a cumulative effects or an "onslaught" on the immune system? If you delay longer than recommended between shots, does it reduce the efficacy of the first one? I am primarily talking about the first 2,4,6 months series.