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I don't really know the safety for sure, but I think short time use is OK. They were doing trials using this drug during labor, so they must have concluded that it was safe for babies for short term use. Since it is relatively new in this country I don't know what info there is about it in breastmilk and such. I don't have my Hale's book here, but I'm not sure Ultram is listed in it. Hmmm, sorry I don't know more. I took it a few times during my pregnancy.